Arsenic Poisoning: Symptoms, Treatment, and More
Causes Diagnosis Treatment Arsenic poisoning is a type of heavy metal poisoning. Arsenic is a metalloid element found naturally in the environment. …Web
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Causes Diagnosis Treatment Arsenic poisoning is a type of heavy metal poisoning. Arsenic is a metalloid element found naturally in the environment. …Web
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Arsenic-contaminated beer resulted in 6,000 poisonings and approximately 71 deaths in Northern England in 1900. Sulfuric acid contaminated with arsenic, which was used to …Web
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General Information Description. Arsenic compounds exist in a number of inorganic and organic forms. This Medical Management Guideline focuses on arsenic trioxide (As 2 O 3), one of the most toxic and prevalent forms.Other inorganic arsenic compounds may vary somewhat in relative toxicity, and organic arsenic compounds appear to be essentially …Web
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Acute arsenic toxicity presents similarly to many gastrointestinal conditions including: Campylobacter Shigella Salmonella …Web
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Arsenic poisoning can affect anyone of any race or age. Children may encounter arsenic as a pesticide, whereas adults are more likely to be exposed through industry or occupational environments. ... swelling of the nerve fiber layer in the arcuate bundles above and below the papillomacular bundle may also be seen. Arsenic is a …Web
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Evaluation for arsenic toxicity requires a detailed history, including environmental and occupational exposure history,... For recent and chronic exposure, the 24-hour urine …Web
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Trestrail has since compiled a total of 1026 documented "poisoning crimes" for which the accused person was convicted, including an unstated number of historical cases but also recent killings (20th and …Web
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Definition / general. Arsenic intoxication is associated with acute and chronic adverse health effects. Arsenic is pervasive in water, soil, air; has natural and anthropogenic sources. Its metabolism involves reduction to a trivalent state and oxidative methylation to a pentavalent state; the trivalent arsenicals, including those methylated ...Web
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In general poisoning with inorganic arsenic is commonly seen in cattle, while organic arsenic poisoning is more commonly seen in swine. Arsenic inhibits the activity of sulfhydryl-containing enzymes, which are essential to cellular metabolism. Toxic effects of arsenic are due to blockage of carbohydrate and fat metabolism and cellular respiration.Web
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Lower-dose chronic arsenic exposure can result in subacute toxicity that can include skin changes and skin cancer, peripheral sensorimotor neuropathy, diabetes …Web
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Arsenic poisoning is a type of heavy metal poisoning. Arsenic is a metalloid element found naturally in the environment. Poisoning occurs when a person ingests too much arsenic. This can happen through the contamination of food and water. You can also be exposed to arsenic in the air in the form of a gas.Web
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Arsenic has also been used as a homicidal agent. In cases with absent forthcoming relevant clinical history suggestive of arsenic toxicity, diagnosing cases of an acute arsenic toxicity is extremely challenging because of highly varied and multifaceted clinical presentation. The gastrointestinal (GI) manifestations are usually characteristic in ...Web
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Other findings in acute arsenic poisoning may include fever and facial edema. Several months after poisoning, Mees lines (or Aldrich-Mees lines) may be seen, reflecting transient disruption of nail plate growth during acute poisoning. In episodes of multiple acute exposures, several Mees lines may occur within a single nail. In someWeb
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Arsenic poisoning is not a local problem, it is a global public health concern. ... Although meat and milk contain high levels of arsenic, arsenic toxicity is not commonly seen in domestic animals because arsenic is rapidly excreted in the urine (El Bahri and Romdane, 1991, Faires, 2004).Web
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Even considering that most acute arsenic poisoning occurrences are due to accidental ingestion of arsenic-containing pesticides and less ... Files, D.; Corey, G.R. Arsenic poisoning seen at Duke …Web
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Arsenic is a naturally occurring omnipresent element that exists in three valence states: elemental or metallic arsenic (As0 ), trivalent (arsenite, As 3+ ), and pentavalent (arsenate, As 5+ ). The trivalent form of arsenic (arsenite) is the most toxic and is responsible for the worldwide public health concern about chronic arsenic poisoning.Web
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Figure 1. (A) Rain drop pigmentation seen over posterior aspect of trunk. (B) Mees' lines seen in fingernails. In India ∼80% of the population uses herbal medicine products. 1 Studies have shown that these preparations contain significant amount of heavy metals like arsenic, lead, mercury and cadmium, well above the safety levels. 2 The ...Web
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B. Chronic Poisoning: Chronic arsenic poisoning is much more insidious in nature, often involving multiple hospital admissions before the correct diagnosis is made. Arsenical dermatosis was rarely picked up from the variety of so many dermato sis. The source of arsenic exposure is discovered in fewer than 50% of cases. The mostWeb
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Arsenic is a valuable component in tumor treatment and traditional Chinese medicine and has seen widespread use in processing, manufacturing, and agriculture. Although rare, arsenic poisoning can occur in forensic practice. Elusive pathological changes, as well as obscure clinical signs, may cause arsenic poisoning to go …Web
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Arsenic toxicity has been reported in many countries including China, Pakistan, Bangladesh, ... In liver tissue of C. batrachus and C. punctatus hepatic pathologies were seen in the form of congestion, cloudy hepatocyte swelling, karyolysis, vacuolar degeneration and nuclear hypertrophy dilatation of sinusoids .Web
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Arsenic poisoning may need to be diagnosed based upon clinical symptoms and a source of exposure. Laboratory testing should not delay treatment when a large, life-threating poisoning is suspected. ... On electron microscopy, degenerative changes were seen in mitochondria, microvilli, and endoplasmic reticulum (Danilewicz et al., 1979). For ...Web
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The most obvious and immediate cases of arsenic poisoning have occurred when a large dose of arsenic is taken (or given!) in a short period of time. ... exposure to arsenic. Some of the health problems that have have been seen when people are exposed to high As in drinking water over a long period (such as in Bangladesh) include ...Web
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Experimental animals fed protein-deficient diets while exposed to high levels of arsenic have shown a decreased methylating capacity, which has led to increased deposits of arsenic in liver, lung, and other organ sites, and presumably increased susceptibility to arsenic toxicity. Arsenic can cross the placenta, exposing the fetus.Web
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Periacinar fibrosis and a poorly differentiated cholangiocarcinoma were seen in liver. In pancreas, reduced cell density of islands of Langerhans was noticeable. ... It can be concluded that long-term consumption of arsenic contamined water and forage may be associated with chronic arsenic poisoning in domestic animals and human beings, with ...Web
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Arsenic, which is classified as a Group 1 carcinogen by the International Agency for Research on Cancer, is water-soluble—so it accumulates in rice, which is grown in flooded fields more than ...Web
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Arsenic toxicity from ingested water and food is a worldwide phenomenon capable of causing significant morbidity. Background. Arsenic exists naturally in the environment in various forms; some are toxic, some benign. ... Arsenic cannot be tasted, seen or smelled and can vary in concentration between wells even in a compact area, ...Web
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Acute arsenic poisoning. A 43-year-old male attempted suicide in July, 2001, by drinking 54 g of arsenic trioxide (As 2 O 3 ). The patient, a chemist by profession, prepared this amount of arsenic trioxide in his factory laboratory using a commercial solution of arsenic trichloride (AsCl 3) as a base. He was admitted 5 h later.Web
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Chronic arsenic toxicity affects multiple physiological systems and may cause malignancies leading to death. Exposed individuals, residing in the same area, developed differential dermatological lesion phenotypes and varied susceptibility toward various other arsenic-induced disease risk, even after consuming equivalent amount of …Web
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Laboratory Studies. No specific test is available for arsine exposure; however, arsine exposure may be confirmed by detection of elevated arsenic levels in urine (> 50 mcg/L for a spot test or > 50 mcg for a 24-hour urine test) and signs of hemolysis (eg, hemoglobinuria, anemia, or low haptoglobin). In addition, arsine may be detected in ...Web
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Arsenic is a metalloid ubiquitous in the environment found in different forms (inorganic and organic) and oxidation states (−3, 0, +3, +5). ... Biomarkers of inorganic arsenic exposure are necessary to understand the mechanism of toxicity, and to assess the health impacts. Blood, urine, hair, and nails are the most common biological ...Web
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Arsenic compounds are well absorbed within 24 hours and redistributed to the liver, lungs, intestinal wall, and spleen, where they bind to the sulfhydryl groups of tissue proteins. Arsenic also replaces phosphorus in the bone where it may remain for years. Hence, chronic poisoning can be detected years after exposure has stopped.Web
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Chronic arsenic toxicity is associated with various clinical manifestations known as arsenicosis. Pigmentation and keratosis are the specific skin lesion characteristics of chronic arsenic toxicity. ... [14], although less commonly seen. Pigmentation is not histopathologically related to arsenical hyperkeratosis, nor is it a direct precursor of ...Web
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Arsine is a colorless, flammable, and highly toxic gas. It has a garlic-like or fishy odor that can be detected at concentrations of 0.5 ppm and above. Because arsine is nonirritating and produces no immediate symptoms, persons exposed to hazardous levels may be unaware of its presence. Arsine is water soluble. It is generally shipped in cylinders as a liquefied …Web
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Initial symptoms of acute arsenic trioxide poisoning (occurring within 30 minutes to several hours) include burning of the lips, pharyngeal constriction, severe abdominal pain, and …Web
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